As a global industry leader in CDMO services for microbial expression systems, Yaohaibio is committed to an open, comprehensive, and integrated CRO/CDMO/MAH service platform. Supported by our unrivaled technology platform, mature quality management system, and advanced mRNA synthesis technologies, we can provide customized mRNA synthesis services worldwide. In addition, preprepared mRNA products and customized services for different experiments and projects demands were also available!
mRNA structure design and optimization platform
mRNA synthesis and modification platform
mRNA purification platform
mRNA quality analysis and control platform
| Optimal design for 5' UTR and 3' UTR | Optimal design of CDS area | Optimal design of PolyA tail |
Diverse source selection of UTR
Frontier CDS optimization cooperation team
More stable PolyA tail design
| Design and construction of mRNA template plasmid; | Synthesis of conventional mRNA (including Cap and PolyA); | Synthesis of nucleotide-modified mRNA (e.g.,ψ, 5mC) |
FreeCut template plasmid design;
Prolific and stable mRNA synthesis system;
Diverse mRNA nucleotide modification options.
| LiCl precipitation purification | Oligo dT magnetic bead purification | Chromatographic column process purification |
Diverse purification methods
Proven self-developed chromatographic purification process
| Denatured gel electrophoresis (formaldehyde) purity testing system | Translation expression detection system | Capping rate testing system | PolyA distribution detection system |
General quality control indicators such as concentration and purity
Satisfy special quality control requirements such as mRNA translation testing, capping rate, tail distribution, etc.
mRNA_eGFP (Transfection Control);
mRNA_1273 (Moderna Vaccine);
mRNA_162b2 (Pfizer Vaccine);
mRNA_mCherry（Transfection Control) ;
mRNA_luciferase（Transfection Control);
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Design and construction of mRNA template plasmid
Preparation of classical mRNA (cap structure, PolyA tail structure)
Preparation of nucleotide modified mRNA (pseudouracil, N1 methyl pseudouracil, 5 methylcytidine)
Preparation of two genes expressing based on a single mRNA sequence
Other customized mRNAs
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TEL: +86-523-86285566
Address: Building 29, No. 801, Jiankang Avenue, Taizhou, Jiangsu
Email: BD@yaohaibio.cn
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